In pursuit of influenza: Fort monmouth to valhalla (and back)
Identifieur interne : 001B80 ( Main/Exploration ); précédent : 001B79; suivant : 001B81In pursuit of influenza: Fort monmouth to valhalla (and back)
Auteurs : Edwin D. Kilbourne [États-Unis]Source :
- BioEssays [ 0265-9247 ] ; 1997-07.
English descriptors
- Teeft :
- Acad, Academic press, Antigenic, Antigenic competition, Antigenic hybrids, Antigenic markers, Antigenic reactivity, Antiviral activity, Basic research, Cell monolayers, Chick, Chick embryo, Correlated studies, Cortisone, Embryo, Epidemiology, Experimental animals, Experimental transmission, Fort monmouth, Genetic, Genetic approach, Genetic dimorphism, Genetic reassortment, Genetic recombination, Genetic studies, Genetics, Glycoprotein, Hemagglutinin, Horsfall, Hybrid, Individual plaques, Infection, Influenza, Influenza vaccination, Influenza vaccine, Influenza vaccines, Influenza virus, Influenza virus genetics, Influenza virus hemagglutinin, Influenza virus infection, Influenza viruses, Intravirionic antigenic competition, Kilbourne, Laver, Major antigens, Major virus glycoproteins, Molecular epidemiology, Multiplicity reactivation, Mutant, Natl acad, Natural infection, Neuraminidase, Neuraminidase antibody, Novel approach, Pandemic, Pandemic strains, Plaque, Plenum press, Practical application, Proc, Protective effects, Reassortment, Recombinant, Recombinant vaccine, Replication, Schulman, Serial passage, Single gene reassortants, Structural proteins, Subtype viruses, Surface antigens, Swine, Swine influenza virus, Vaccine, Vaccine production, Viral, Viral morphology, Viral replication, Viral virulence, Virol, Virus, Virus particles, Virus yields.
Abstract
In reviewing 50 years of personal research on influenza, I have journeyed, literally and figuratively, from an army camp epidemic in Fort Monmouth NJ in 1947 to a (literal and figurative) Valhalla, where I now conduct my research. Having entered the field as a physician, I have always sought practical applications of my work, yet in every instance, such applications have led me to seek further answers in basic research as new questions arose. I entered the area of influenza virus genetics by the back door through an interest in the effects of corticosteroid hormones on viral replication, used the genetic approach in analyzing the morphological variation of the virus and, in so doing, exploited the finding of a linkage of high‐yield growth to spherical morphology. Today, all influenza vaccine viruses are high‐yield genetic reassortants. Subsequent study of reassortant viruses facilitated the identification and isolation of the two major antigens of the virus in antigenic hybrids and showed their differing functions in the induction of immunity. In turn, a new approach to influenza vaccination has been discovered and is presently under clinical investigation.
Url:
DOI: 10.1002/bies.950190715
Affiliations:
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Having entered the field as a physician, I have always sought practical applications of my work, yet in every instance, such applications have led me to seek further answers in basic research as new questions arose. I entered the area of influenza virus genetics by the back door through an interest in the effects of corticosteroid hormones on viral replication, used the genetic approach in analyzing the morphological variation of the virus and, in so doing, exploited the finding of a linkage of high‐yield growth to spherical morphology. Today, all influenza vaccine viruses are high‐yield genetic reassortants. Subsequent study of reassortant viruses facilitated the identification and isolation of the two major antigens of the virus in antigenic hybrids and showed their differing functions in the induction of immunity. In turn, a new approach to influenza vaccination has been discovered and is presently under clinical investigation.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Kilbourne, Edwin D" sort="Kilbourne, Edwin D" uniqKey="Kilbourne E" first="Edwin D." last="Kilbourne">Edwin D. Kilbourne</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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